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[Resistance to antibiotics caused by decrease of the permeability in gram-negative bacteria]

J C Nguyen Van1, L Gutmann

  • 1Laboratoire de Microbiologie médicale, Hôpital Broussais, Paris.

Presse Medicale (Paris, France : 1983)
|March 19, 1994
PubMed
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Gram-negative bacteria resist antibiotics via reduced outer membrane permeability. This mechanism hinders antibiotic entry, leading to cross-resistance and posing clinical challenges, especially in species like Pseudomonas aeruginosa.

Area of Science:

  • Microbiology
  • Bacterial Pathogenesis
  • Antimicrobial Resistance

Context:

  • Gram-negative bacteria possess a unique outer membrane that acts as a barrier.
  • This membrane restricts the entry of various molecules, including antibiotics.
  • Reduced permeability is a significant resistance mechanism in these bacteria.

Purpose:

  • To elucidate the role of the Gram-negative outer membrane in antibiotic resistance.
  • To explain the mechanism of reduced permeability and its impact on antibiotic diffusion.
  • To highlight the clinical relevance and associated bacterial species.

Summary:

  • Gram-negative bacteria's outer membrane, with its specific aqueous pores (1-1.2 nm diameter), limits antibiotic penetration.
  • Alterations in pore number or function decrease antibiotic diffusion, conferring resistance.

Related Experiment Videos

  • This reduced permeability mechanism can lead to cross-resistance and is observed in Enterobacteriaceae and Pseudomonas aeruginosa.

    • Impact:

    • Reduced permeability contributes to treatment failures and the emergence of multidrug-resistant bacteria.
    • Understanding this mechanism is crucial for developing novel therapeutic strategies.
    • Clinical incidence is underestimated due to detection challenges, impacting patient outcomes.