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Modified seroneutralization assay for measles virus antibody detection
S V Nates1, G Y Rey, M O Giordano
1Instituto de Virología, Dr. J.M. Vanella, Facultad de Cencia Médicas, Unversidad Nacional de Córdoba, Ciudad Universitaria, Argentina.
Research in Virology
|January 1, 1994
Abstract:
We describe a simple, inexpensive, sensitive and specific modified seroneutralization assay for use on a wide scale to screen for the presence of measles antibodies. After only one reaction (1 h) and a 3-day incubation period at 37 degrees C, the test can be easily read using a rapid, inexpensive methylene blue/phenol staining procedure. The determination of protective antibody titres by modified and standard seroneutralization methods was strongly correlated (corr. coff. = 0.98).