Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A multiple decision procedure in clinical trials

T T Chen1, R Simon

  • 1Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892.

Statistics in Medicine
|March 15, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative strain typing of Rhizobium leguminosarum bv. viciae natural populations.

Canadian journal of microbiology·2001
Same author

Impact of 2,4-diacetylphloroglucinol-producing biocontrol strain Pseudomonas fluorescens F113 on intraspecific diversity of resident culturable fluorescent pseudomonads associated with the roots of field-grown sugar beet seedlings.

Applied and environmental microbiology·2001
Same author

Distal chromosome 17 gains in neuroblastomas detected by comparative genomic hybridization (CGH) are associated with a poor clinical outcome.

Medical and pediatric oncology·2001
Same author

Control of cell fate in plant meristems.

Novartis Foundation symposium·2001
Same author

A molecular link between stem cell regulation and floral patterning in Arabidopsis.

Cell·2001
Same author

Combinatorial peptide libraries as an alternative approach to the identification of ligands for tumor-reactive cytolytic T lymphocytes.

Cancer research·2001
Same journal

Interpretable Bayesian Modeling for Multireader Multicase Studies: Addressing Overdispersion and Limited Sample Size in Diagnostic Enhancement Evaluation.

Statistics in medicine·2026
Same journal

Adaptive Sequential Multiple Hypotheses Testing for Concomitant Vaccine Safety Surveillance.

Statistics in medicine·2026
Same journal

Novel Distance Regression for Repeated Outcomes With Missing Data: Applications to Longitudinal and Crossover Studies of Microbiome Beta-Diversity.

Statistics in medicine·2026
Same journal

Optimal Weighted Tests for Replication Studies and the 'Two-Trials Rule' With Multiple Hypotheses.

Statistics in medicine·2026
Same journal

Identifiable Copula-Double-Cox Models: A Fully Parametric Framework for Dependent Right-Censored Survival Data.

Statistics in medicine·2026
Same journal

Moving From Individualized Risk-Based Prevention to Benefit-Based Prevention: Estimating Individualized Life-Years Gained From Prevention Services as a Basis for Eligibility.

Statistics in medicine·2026
See all related articles

This study introduces decision procedures for clinical trials with equally preferred treatments, ensuring high selection probability for correct therapies. Sample size requirements are provided for normal, binomial, and exponential endpoints.

Area of Science:

  • Clinical Trials Methodology
  • Biostatistics
  • Experimental Design

Background:

  • Clinical trials often rank treatments by secondary factors like toxicity or cost.
  • Situations arise where multiple treatments have equal prior preference.

Purpose of the Study:

  • To develop decision procedures for clinical trials with equally preferred treatments.
  • To ensure a high probability of selecting the correct treatment(s).

Main Methods:

  • Formulating decision procedures for scenarios with multiple equally preferred treatments.
  • Establishing sample size requirements for these procedures.

Main Results:

  • The proposed decision procedures guarantee a high selection probability for correct treatments.

Related Experiment Videos

  • Sample size requirements are derived for various endpoint types.

    • Conclusions:

    • The developed methods are applicable to clinical trials comparing equally preferred treatments.
    • The procedures support trials with normal, binomial, or right-censored exponential endpoints.