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[Lissencephaly. Clinical, electroencephalographic and radiological aspects]
M Giroud1, C François, C Durand
1Service de Neurologie, CHU, Dijon.
Revue Neurologique
|January 1, 1993
Summary
We present two cases of lissencephaly, a brain malformation characterized by smooth cortex. Findings suggest this neuronal migration disorder may not originate from radial glial fibers.
Area of Science:
- Neuroscience
- Developmental Biology
- Medical Imaging
Background:
- Lissencephaly is a severe brain malformation.
- Key symptoms include microcephaly, intellectual disability, and epilepsy.
Observation:
- Two cases of lissencephaly were analyzed.
- Computed Tomography (CT) scans and Magnetic Resonance Imaging (MRI) were utilized.
Findings:
- Anatomical abnormalities observed: microcephaly, smooth cortex, reduced white matter volume, and absent sulci/gyri.
- Normal myelin on MRI suggests a disruption in neuronal migration not related to radial glial fibers.
Implications:
- This study contributes to understanding the etiology of lissencephaly.
- Further research into neuronal migration pathways is warranted.