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[Proteinuria in diabetic disease]

M Camici1, E Iazzolino, L Evangelisti

  • 1Insegnamento Metodologia Clinica, Istituto di Clinica Medica II, Università degli Studi di Pisa.

Minerva Urologica E Nefrologica = the Italian Journal of Urology and Nephrology
|December 1, 1993
PubMed
Summary

This study on primitive diabetes mellitus found that evaluating plasma protein electrophoresis and glycosylated hemoglobin is crucial. These markers help understand kidney function and edema in diabetic patients.

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Area of Science:

  • Endocrinology
  • Nephrology
  • Clinical Chemistry

Background:

  • Primitive diabetes mellitus presents complex metabolic and renal challenges.
  • Disprotidemic patterns and altered protein excretion are observed in diabetic patients.
  • Glycosylated hemoglobin (HbA1c) is a key indicator of long-term glycemic control.

Purpose of the Study:

  • To investigate the incidence of disprotidemia in primitive diabetes mellitus.
  • To analyze the relationship between urinary protein excretion, renal function, and glycemic control.
  • To determine the clinical significance of plasma protein electrophoresis and HbA1c in this population.

Main Methods:

  • Epidemiological study involving 397 patients with primitive diabetes mellitus.
  • Assessment of total urinary protein excretion over 24 hours.

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  • Evaluation of renal function parameters, plasma protein electrophoretic patterns, and glycosylated hemoglobin levels.
  • Monitoring for the presence of edema.

    • Main Results:

    • The study identified a significant incidence of the disprotidemic pattern in the studied cohort.
    • Alterations in total urinary protein excretion and renal function were observed.
    • Plasma glycosylated hemoglobin levels correlated with observed clinical manifestations.
    • A notable association between these markers and the presence of edema was found.

    Conclusions:

    • The findings underscore the importance of evaluating plasma protein electrophoresis in diabetic patients.
    • Monitoring glycosylated hemoglobin is essential for assessing disease progression and complications.
    • These assessments are vital for understanding and managing renal function and edema in primitive diabetes mellitus.