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Leukocyte aggregation in patients with a previous cerebral ischemic event
M Silvestrini1, A Pietroiusti, A Magrini
1Clinic of Neurology, Tor Vergata University of Rome, Italy.
Stroke
|July 1, 1994
Summary
Leukocyte aggregation, a blood flow alteration, was significantly higher in patients with recent ischemic stroke compared to controls. This finding suggests a link between leukocyte aggregation and cerebrovascular disease risk.
Area of Science:
- Hemorheology
- Cerebrovascular Medicine
- Hematology
Background:
- The role of leukocyte aggregation in ischemic stroke pathogenesis remains debated.
- Hemorheologic alterations, specifically leukocyte aggregation, are implicated in various vascular conditions.
Purpose of the Study:
- To investigate the hemorheologic alteration of leukocyte aggregation in patients at risk for stroke.
- To determine if elevated leukocyte aggregation is associated with recent cerebral ischemic events.
Main Methods:
- Leukocyte aggregation was quantified using the leukergy test.
- The study included 61 patients with recent cerebral ischemic events and 61 healthy control subjects.
Main Results:
- Leukocyte aggregation was significantly elevated in patients with ischemic stroke compared to controls (3.8% vs. 2.5%, P = .01).
- In control subjects, vascular risk factors correlated with leukocyte aggregation levels similar to those seen in stroke patients.
Conclusions:
- Altered leukocyte aggregation is associated with cerebrovascular disease.
- Further research is warranted to establish leukocyte aggregation as a potential marker for increased stroke risk.