Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human leucocyte migration inhibition

G Bendixen, K Bendtzen, J E Calusen

    Scandinavian Journal of Immunology
    |June 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes.

    Rheumatology international·2014
    Same author

    Cytokines and soluble IL-4 in patients with acute optic neuritis and multiple sclerosis.

    European journal of neurology·2013
    Same author

    Commentary: antibodies reacting with the infliximab Fab portion--something new? Authors' reply.

    Alimentary pharmacology & therapeutics·2013
    Same author

    Pre-existing IgG antibodies cross-reacting with the Fab region of infliximab predict efficacy and safety of infliximab therapy in inflammatory bowel disease.

    Alimentary pharmacology & therapeutics·2013
    Same author

    Letter: persistence of anti-infliximab antibodies after discontinuation of infliximab in patients with IBD.

    Alimentary pharmacology & therapeutics·2012
    Same author

    Genetic polymorphisms of tumour necrosis factor receptor superfamily 1b and fas ligand are associated with clinical efficacy and/or acute severe infusion reactions to infliximab in Crohn's disease.

    Alimentary pharmacology & therapeutics·2012
    Same journal

    Recent Thymic Emigrant Levels in Inborn Errors of Immunity: Is Their Diagnostic Value Greater Than We Think?

    Scandinavian journal of immunology·2026
    Same journal

    The EBNA-1 Conundrum: Does Epstein-Barr Virus Invoke Autoimmune Pathology in a Population Subset by Poorly Purine-Loading Its Major Latency-Maintaining Transcript?

    Scandinavian journal of immunology·2026
    Same journal

    Unsupervised Flow Cytometry Reveals a Constant Shift Towards Activated CD4<sup>+</sup> T Cell Subsets in APECED.

    Scandinavian journal of immunology·2026
    Same journal

    RETRACTION: Interleukin-13 Induces T Helper Type 2 Immune Responses in OVA-Immunized BALB/c Mice Bearing a T Cell Lymphoma.

    Scandinavian journal of immunology·2026
    Same journal

    Development of a Detection Method for Soluble Urokinase-Type Plasminogen Activator Receptor and Its Application in Predicting Prognosis of Severe COVID-19.

    Scandinavian journal of immunology·2026
    Same journal

    Crohn's Disease Enteritis: Pathophysiological Mechanisms and Therapeutic Approaches.

    Scandinavian journal of immunology·2026
    See all related articles

    Detecting cell-mediated immunity in humans is now possible using leucocyte migration inhibition tests. These in vitro methods, including leucocyte migration capillary tube technique (LMCT) and leucocyte migration agarose technique (LMAT), offer valuable insights into immune responses.

    Area of Science:

    • Immunology
    • Cellular Biology

    Background:

    • Cell-mediated immunity plays a crucial role in various physiological and pathological processes.
    • In vitro techniques are essential for studying immune responses without direct in vivo manipulation.

    Purpose of the Study:

    • To describe and detail established in vitro techniques for detecting cell-mediated immunity in humans.
    • To outline the applications of these techniques in understanding immunobiology and clinical conditions.

    Main Methods:

    • Detailed description of the leucocyte migration capillary tube technique (LMCT).
    • Detailed description of the leucocyte migration agarose technique (LMAT), including indirect LMAT.
    • Procedure for antigen concentration selection and concanavalin A-induced lymphocyte release assay.

    Related Experiment Videos

    Main Results:

    • Established LMCT and LMAT as reliable methods for assessing cell-mediated immunity.
    • Demonstrated the utility of these techniques in exploring lymphocyte immunobiology and cellular interactions.
    • Highlighted applicability in diverse clinical conditions such as infectious, autoimmune, and tumor diseases.

    Conclusions:

    • Leucocyte migration inhibition techniques (LMCT and LMAT) are valuable tools for studying human cell-mediated immunity.
    • Adaptation of these methods to specific experimental aims is crucial for optimal results.
    • Increased use of purified antigens and indirect assays can enhance the utility of these techniques.