Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Predictive factors for post-poliomyelitis syndrome

D A Trojan1, N R Cashman, S Shapiro

  • 1Department of Neurology, Montreal Neurological Institute, Quebec, Canada.

Archives of Physical Medicine and Rehabilitation
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risks and consequences of TB and its prevention in cost-utility analyses among immigrants: a systematic review.

IJTLD open·2025
Same author

The prion-like nature of amyotrophic lateral sclerosis.

Progress in molecular biology and translational science·2020
Same author

Creutzfeldt-Jakob disease mortality in Canada, 1998 to 2013.

Canada communicable disease report = Releve des maladies transmissibles au Canada·2018
Same author

Propagated protein misfolding: New opportunities for therapeutics, new public health risk.

Canada communicable disease report = Releve des maladies transmissibles au Canada·2018
Same author

Relationship between physical activity and hip pain in persons with and without cam or pincer morphology: a population-based case-control study.

Osteoarthritis and cartilage·2017
Same author

The validity of a non-radiologist reader in identifying cam and pincer femoroacetabular impingement (FAI) using plain radiography.

Rheumatology international·2015

New weakness and fatigue in polio survivors may be predicted by factors like age, initial polio severity, and pain. Understanding these predictors can help identify individuals at risk for post-polio syndrome (PPS).

Area of Science:

  • Neurology
  • Epidemiology
  • Rehabilitation Medicine

Background:

  • Post-poliomyelitis syndrome (PPS) is characterized by new weakness, fatigue, and pain in individuals with a history of paralytic poliomyelitis.
  • Identifying predictive factors for PPS is crucial for early intervention and management.

Purpose of the Study:

  • To identify factors that predict the development of post-polio syndrome (PPS) in patients with a history of paralytic poliomyelitis.
  • To utilize a case-control study design to analyze risk factors associated with PPS.

Main Methods:

  • A case-control study was conducted involving patients from a university-affiliated hospital post-polio clinic.
  • Data were collected through a chart review of 353 patients (127 cases with new weakness/fatigue, 39 controls without).

Related Experiment Videos

  • Logistic regression modeling was employed to determine odds ratios for various risk factors.

    • Main Results:

    • Univariate analysis identified greater age at presentation, longer time since acute polio, and greater weakness during acute polio as significant risk factors.
    • Associated factors included recent weight gain, muscle pain (especially with exercise), and joint pain.
    • Multivariate analysis indicated that age at presentation, severity of weakness during acute polio, muscle pain with exercise, recent weight gain, and joint pain were key predictors distinguishing cases from controls.

    Conclusions:

    • The degree of initial motor unit involvement, indicated by weakness during acute polio, is a significant predictor of PPS.
    • The aging process and overuse may also play roles in the development of post-polio syndrome.
    • Factors such as age at presentation, acute polio severity, exercise-induced muscle pain, weight gain, and joint pain help predict PPS.