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Induction of experimental allergic arthritis with outer surface proteins of Borrelia burgdorferi
K B Gondolf1, M Mihatsch, E Curschellas
1Institute for Medical Microbiology, Freiburg, Germany.
Arthritis and Rheumatism
|July 1, 1994
Abstract
Objective:
The arthritogenic potential of the cationic outer surface proteins (Osp) from Borrelia burgdorferi was tested in rats.
Methods:
Water-soluble Osps were prepared by butanol extraction and were administered by intraarticular injection. Tissue injury was assessed by scintigraphy and histology.
Results:
A mild arthritis was seen in naive rats. Preimmunized animals had more severe, longer lasting bouts of inflammation.
Conclusion:
The Osps of Borrelia burgdorferi are potent arthritogens in rats. These immunodominant antigens may play a role in the development of Lyme arthritis in humans.