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Hypocomplementemic urticarial vasculitis syndrome in identical twins

J J Wisnieski1, S N Emancipator, N J Korman

  • 1Medical Research Service, VA Medical Center, Cleveland, OH 44106.

Arthritis and Rheumatism
|July 1, 1994
PubMed
Summary

Hypocomplementemic urticarial vasculitis syndrome (HUVS) appeared in identical twins, suggesting a genetic component. This concordance indicates abnormal genetic immunoregulation may play a role in HUVS development.

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Area of Science:

  • Immunology
  • Genetics
  • Rheumatology

Background:

  • Hypocomplementemic urticarial vasculitis syndrome (HUVS) is characterized by recurrent urticarial vasculitis, hypocomplementemia, and arthralgia/arthritis.
  • Clinical manifestations can also include angioedema, ocular inflammation, glomerulonephritis, and obstructive lung disease.
  • The etiology of HUVS remains unknown, but its similarities to systemic lupus erythematosus (SLE) suggest a shared pathogenic pathway.

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