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Related Experiment Videos

Patient with unusual alternating hemiplegia

T Nishiki1, Y Takeuchi, I Yamazoe

  • 1Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.

Pediatric Neurology
|March 1, 1994
PubMed
Summary

This study reports a rare case of alternating hemiplegia in childhood. Flunarizine treatment significantly reduced hemiplegic episodes, suggesting its therapeutic benefit.

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Area of Science:

  • Neurology
  • Pediatric Neurology

Background:

  • Alternating hemiplegia of childhood (AHC) is a rare neurological disorder characterized by recurrent episodes of unilateral weakness.
  • This case presents an unusual AHC presentation with lower episode frequency and specific neuroimaging findings.

Observation:

  • The patient exhibited decreased cerebral blood flow in the left hemisphere on interictal positron emission tomography.
  • Cerebral angiography precipitated hemiplegic episodes and coma in the patient, suggesting a potential trigger.

Findings:

  • Cerebral angiography may trigger hemiplegic episodes and coma in children with alternating hemiplegia.
  • Flunarizine treatment led to a near-complete disappearance of hemiplegic episodes for six years.

Implications:

  • This case highlights a potential iatrogenic risk associated with cerebral angiography in AHC patients.
  • Flunarizine demonstrates significant efficacy in managing alternating hemiplegia, offering a promising therapeutic option.

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