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Related Experiment Videos

Hyperthyroidism associated with hyperemesis gravidarum

A J Krentz1, H Redman, K G Taylor

  • 1Department of Diabetes, Endocrinology and Lipid Metabolism, Dudley Road Hospital, Birmingham.

The British Journal of Clinical Practice
|March 1, 1994
PubMed
Summary

Distinguishing transient hyperthyroidism in pregnancy from Graves' disease is challenging. This study suggests some cases of hyperemesis gravidarum involve transient thyroid hormone elevation, not autoimmune thyroid disease, questioning the need for antithyroid drugs.

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Area of Science:

  • Endocrinology
  • Obstetrics
  • Reproductive Medicine

Background:

  • Hyperemesis gravidarum can be linked to hyperthyroidism, often due to Graves' disease.
  • A distinct syndrome of transient hyperthyroidism associated with hyperemesis gravidarum, resolving spontaneously, is also recognized.
  • Differentiating these conditions is clinically important but can be difficult.

Observation:

  • Two cases of severe hyperemesis gravidarum with hyperthyroidism are presented.
  • One patient's intractable hyperemesis persisted despite normalized thyroid hormone levels with carbimazole.
  • Neither patient showed signs of autoimmune thyroid disease.

Findings:

  • The presented cases suggest transient hyperthyroxinemia of hyperemesis gravidarum, rather than Graves' disease.

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  • The clinical and immunological features did not support an autoimmune etiology.
  • This challenges the routine use of antithyroid drugs in such cases.

    • Implications:

    • The role of antithyroid drugs in managing transient hyperthyroidism associated with hyperemesis gravidarum needs further investigation.
    • Accurate diagnosis is crucial to avoid unnecessary treatment with antithyroid medications.
    • Further research is required to clarify diagnostic criteria and treatment guidelines.