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[Neuronal development and apoptosis]

T Koike1, S Tanaka, E Ito

  • 1Graduate Program in Biological Sciences, Hokkaido University, Sapporo, Japan.

Human Cell
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

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This review explores nuclear neuronal cell death mechanisms, focusing on apoptosis in superior cervical ganglion and PC12 cells. It highlights presynaptic regulation and cerebellar granule cell pathways, with implications for development.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Context:

  • Neuronal cell death is crucial during development.
  • Nuclear apoptosis, characterized by cell shrinkage and chromatin condensation, is a key mechanism.
  • In vitro models like SCG and PC12 cells provide insights into neuronal apoptosis.

Purpose:

  • To review recent advances in understanding the mechanisms of nuclear neuronal cell death in vitro.
  • To focus on apoptosis in superior cervical ganglion (SCG) and PC12 cells upon nerve growth factor (NGF) deprivation.
  • To discuss the role of presynaptic regulation and cerebellar granule cell development in neuronal survival.

Summary:

  • Apoptosis in SCG and PC12 cells is triggered by NGF or serum/NGF deprivation.
  • Cholinergic and non-cholinergic innervations presynaptically regulate SCG cell death via Ca2+ and cAMP pathways, respectively.

Related Experiment Videos

  • Cerebellar granule cell death mechanisms are linked to cerebellum development and synaptogenesis, with implications from fyn knockout models.

    • Impact:

    • Provides a concise overview of in vitro neuronal apoptosis mechanisms.
    • Elucidates the role of specific signaling pathways (Ca2+, cAMP) in neuronal survival.
    • Offers insights into developmental neurobiology and potential implications for neurological disorders.