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Related Experiment Videos

msd is required for mesoderm induction in mice

B C Holdener1, C Faust, N S Rosenthal

  • 1Department of Genetics, Case Western Reserve University, Cleveland, OH 44106-4955.

Development (Cambridge, England)
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

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Mutations in the msd gene block mesoderm induction in mouse embryos, preventing the formation of essential embryonic tissues. This defect highlights the gene's crucial role in early vertebrate development and response to developmental signals.

Area of Science:

  • Developmental Biology
  • Genetics
  • Embryology

Background:

  • Mesoderm induction is essential for vertebrate body plan formation.
  • Mutations affecting this process are key to understanding early development.
  • The msd (mesoderm deficiency) mutation in mice provides a model to study these mechanisms.

Purpose of the Study:

  • To investigate the role of the msd mutation in mesoderm development.
  • To determine the specific defects caused by the msd mutation during embryogenesis.
  • To understand the molecular basis of mesoderm induction failure.

Main Methods:

  • Analysis of msd-deficient mouse embryos and embryonic stem (ES) cells.
  • Examination of transcript distribution to assess gene expression patterns.

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  • Assessment of differentiation capabilities of affected embryos and cells.

    • Main Results:

    • Msd-deficient embryos lack mesoderm but possess developed ectoderm and extraembryonic tissues.
    • Gastrulation-related gene expression is initiated but primitive streak formation and mesoderm induction are blocked.
    • Msd-deficient embryos and ES cells exhibit impaired mesodermal differentiation but retain ectodermal differentiation potential.

    Conclusions:

    • The msd mutation specifically disrupts mesoderm formation.
    • The defect may stem from an inability to respond to inductive signals required for mesoderm development.
    • This study elucidates a critical genetic component in vertebrate mesoderm induction.