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MHCDB--database of the human MHC

W R Newell1, J Trowsdale, S Beck

  • 1Imperial Cancer Research Fund, London, UK.

Immunogenetics
|January 1, 1994
PubMed
Summary

A new database, MHCDB, integrates human major histocompatibility complex (MHC) genetic and physical data. This comprehensive resource facilitates rapid access to diverse genomic information for MHC research.

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Area of Science:

  • Genomics
  • Immunogenetics

Background:

  • The human major histocompatibility complex (MHC) is a critical region for immune function.
  • Comprehensive and integrated data on the human MHC are essential for advanced research.

Purpose of the Study:

  • To develop and present a centralized database (MHCDB) for human MHC genetic and physical data.
  • To provide a user-friendly tool for accessing and analyzing complex MHC information.

Main Methods:

  • Compilation and analysis of genetic and physical mapping data for the human MHC.
  • Utilizing a genome analysis program for data integration and management.
  • Inclusion of genomic DNA sequence, gene locations, clone data, and allele sequences.

Main Results:

  • MHCDB contains over 100 gene/marker locations and 250 YAC/cosmid clone locations.
  • Includes 150 kb of annotated genomic DNA sequence and known class I/II allele cDNA sequences.
  • Provides associated descriptive data such as references and contact information.

Conclusions:

  • MHCDB offers a valuable, publicly accessible resource for human MHC research.
  • The database facilitates rapid data retrieval and display, aiding scientific study.
  • MHCDB will be updated with new data as they become available.

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