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[Current scopes on tissue factor: its physiological function and relationship with coagulation diseases]

S Nakamura1

  • 1Department of Cellular and Molecular Biology, Kyoto University.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

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Tissue factor (TF) expressed by immune cells initiates blood clotting, aiding host defense but also risking vascular diseases. Elevated TF levels in cancer and leukemia patients link to coagulation disorders.

Area of Science:

  • Biochemistry
  • Immunology
  • Hematology

Context:

  • Immune cells like monocytes/macrophages and endothelial cells express tissue factor (TF) upon activation during immune responses or inflammation.
  • TF initiates the extrinsic blood clotting pathway, leading to thrombin generation and fibrin deposition.
  • This process plays a role in host defense but is also implicated in vascular pathologies.

Purpose:

  • To elucidate the role of tissue factor (TF) in cellular activation, blood coagulation, and disease pathogenesis.
  • To highlight the dual role of TF in host defense and its association with vascular diseases.
  • To underscore the clinical significance of elevated TF levels in cancer and leukemia patients with coagulation disorders.

Summary:

  • Monocytes/macrophages and endothelial cells express tissue factor (TF) when activated by inflammation or immune responses.

Related Experiment Videos

  • TF triggers blood clotting, forming fibrin around cells, which can be part of host defense.
  • TF expression is a risk factor for vascular diseases like arteriosclerosis and thrombosis, and elevated levels are seen in cancer/leukemia patients with DIC.

    • Impact:

    • Understanding TF's role can lead to novel therapeutic strategies for thrombotic and inflammatory diseases.
    • Identifying TF as a risk factor aids in predicting and managing vascular complications.
    • Monitoring TF levels may improve diagnosis and treatment of coagulation disorders in hematologic malignancies.