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Nomenclature for factors of the HLA system, 1977
Bulletin of the World Health Organization
|January 1, 1978
Insights
The World Health Organization (WHO) nomenclature committee updated rules for human leukocyte antigen (HLA) specificities. This includes new HLA statuses and provisional designations for HLA-B, HLA-C, and HLA-D loci.
Area of Science:
- Immunogenetics
- Molecular Biology
- Cell Biology
Background:
- Human Leukocyte Antigen (HLA) system is crucial for immune response.
- Accurate nomenclature is essential for understanding HLA diversity and function.
- Previous classifications required updates to reflect new discoveries.
Purpose of the Study:
- To report decisions from the WHO nomenclature committee on leukocyte antigens.
- To update the official HLA typing nomenclature.
- To standardize the classification of newly identified HLA specificities.
Main Methods:
- Review of serological data on B lymphocytes.
- Analysis of genetic and antigenic properties of HLA loci.
- Consensus-based decision-making by the WHO nomenclature committee.
Main Results:
- Upgrading of specific HLA-A and HLA-B antigen specificities to full HLA status.
- Designation of new provisional specificities for HLA-B, HLA-C, and HLA-D loci.
- Establishment of a standardized nomenclature for novel B lymphocyte-specificities.
Conclusions:
- The updated nomenclature enhances the precision of HLA typing.
- Standardization facilitates global communication and research in transplantation and disease association studies.
- Ongoing refinement of HLA nomenclature is vital for advancing immunogenetic research.
Abstract:
This article gives the decisions of the WHO nomenclature committee on leukocyte antigens, in particular concerning (a) the upgrading of certain HLA-A and HLA-B specificities to full HLA status, (b) the designation of new provisional specificities of the HLA-B, HLA-C, and HLA-D loci, and (c) the establishment of a nomenclature for the new specificities identified by serological techniques on B lymphocytes.