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[Cytomegalovirus infection--a review]
K K Hansen1, V Backer, P Skinhøj
1Infektionsmedicinsk afd, Hvidovre Hospital.
Nordisk Medicin
|January 1, 1994
Summary
Human cytomegalovirus (CMV) is a common congenital infection causing birth defects and a serious opportunistic infection in immunocompromised individuals. Early laboratory evaluation and antiviral chemotherapy are crucial for managing CMV disease effectively.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Context:
- Human cytomegalovirus (CMV) is increasingly recognized as a significant cause of human disease.
- It is a common congenital infection linked to birth defects.
- CMV is also a major opportunistic infection in immunocompromised patients, leading to severe illness and mortality.
Purpose:
- To highlight the evolving understanding of human cytomegalovirus (CMV) as a prevalent pathogen.
- To emphasize the importance of diagnosing and managing CMV infections in both congenital and immunocompromised populations.
- To underscore the effectiveness of antiviral treatments for CMV disease.
Summary:
- CMV, an enveloped DNA virus from the herpes family, is prevalent, with 50-60% of Danish blood donors having anti-CMV antibodies.
- Prevalence varies based on demographic and behavioral factors.
- Diagnosis involves laboratory evaluation of symptomatic or reactivated infections.
Impact:
- Increased awareness of CMV's impact on congenital health and immunocompromised individuals.
- Promotes timely diagnosis and intervention for CMV infections.
- Supports the use of antiviral chemotherapy (e.g., ganciclovir, foscarnet) for effective CMV disease management.