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Related Experiment Videos

Hypoglycaemia unawareness

E Meijer1, J B Hoekstra, D W Erkelens

  • 1Department of Internal Medicine, Academic Hospital, Utrecht, The Netherlands.

Presse Medicale (Paris, France : 1983)
|April 2, 1994
PubMed
Summary
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Hypoglycaemia unawareness in diabetes is linked to good blood sugar control, not human insulin. Impaired adrenaline secretion may cause this, but its cause is unknown and not due to diabetic autonomic neuropathy.

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Diabetes Mellitus Research

Background:

  • Hypoglycaemia is a severe complication of insulin-dependent diabetes mellitus (IDDM).
  • Hypoglycaemic unawareness, a condition where patients do not sense low blood glucose, increases the risk of severe complications and coma.
  • This unawareness is particularly noted in patients with good glycaemic control and was initially linked to diabetic autonomic neuropathy.

Purpose of the Study:

  • To review the scientific literature regarding the link between hypoglycaemia unawareness and the use of human insulin.
  • To explore the potential pathophysiology of hypoglycaemic unawareness in long-standing IDDM.

Main Methods:

  • Literature review of studies investigating hypoglycaemia unawareness in insulin-dependent diabetes mellitus.

Related Experiment Videos

  • Analysis of factors associated with hypoglycaemic unawareness, including glycaemic control, diabetic autonomic neuropathy, and insulin type.

    • Main Results:

    • The hypothesis that human insulin increases the incidence of hypoglycaemia unawareness is not supported by current scientific literature.
    • Hypoglycaemic unawareness in long-duration IDDM may be related to impaired adrenaline secretion.
    • The cause of impaired adrenaline secretion during hypoglycaemia is currently unknown and does not appear to be a consequence of diabetic autonomic neuropathy.

    Conclusions:

    • Human insulin is unlikely to be a cause of hypoglycaemia unawareness.
    • Impaired adrenaline secretion is a potential factor in the pathophysiology of hypoglycaemic unawareness in long-term IDDM.
    • Further research is needed to elucidate the cause of impaired adrenaline secretion in hypoglycaemia.