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Megavitamin E supplementation in man

P M Farrell1, J G Bieri

  • 1Laboratory of Nutrition and Endocrinology, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, Maryland 20014.

The American Journal of Clinical Nutrition
|December 1, 1975
PubMed
Summary
This summary is machine-generated.

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High-dose vitamin E supplements showed no apparent toxicity in adults over three years. While some reported improved well-being, these benefits were subjective and inconsistent, with no specific health improvements noted.

Area of Science:

  • Nutritional Science
  • Human Physiology
  • Clinical Nutrition

Background:

  • Vitamin E (tocopherol) is a fat-soluble antioxidant with potential health benefits.
  • Concerns exist regarding the safety and efficacy of high-dose vitamin E supplementation.

Purpose of the Study:

  • To evaluate the toxic and beneficial effects of long-term vitamin E supplementation in adults.
  • To assess changes in plasma vitamin E levels and related biomarkers.

Main Methods:

  • 28 adults ingested 100-800 IU/day of tocopherol for an average of 3 years.
  • Subjective health status and medical histories were reviewed.
  • Plasma alpha-tocopherol, carotenoids, vitamin A, and 20 standard clinical blood tests were analyzed.

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Main Results:

  • Plasma alpha-tocopherol levels significantly increased but showed high variability.
  • No gross toxicity or significant disturbances in liver, kidney, or blood parameters were observed.
  • Subjective reports of improved health were inconsistent; no specific benefits were consistently noted.

Conclusions:

  • Megadoses of vitamin E (100-800 IU/day) for 3 years did not produce apparent toxic side effects in this adult group.
  • Subjective claims of beneficial effects from vitamin E supplementation were highly variable and not consistently supported by objective measures.