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[Examination of the heterogeneity of heparin. IV. Crude heparin]
J Jarzebiński1, K Gryz, S Tońska
1Zakład Analizy Leków, Instytut Nauki o Leku, Warszawa.
Acta Poloniae Pharmaceutica
|January 1, 1993
Abstract:
By means of gel chromatography on Sephadex G-15 crude heparin produced at Polfa into four components (71.6%-I, 5.1%-II, 5.8%-III and 17.5%-IV). These components were characterized by different anticoagulant activity (I-110 IU/mg, II-40.0 IU/mg, III-2.0 IU/mg and IV-55.0 IU/mg), what was connected with variable values of molecular weight and of sulphate groups, glucosamine and uronic acids contents.