Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Subendocardial S-T segment changes during acute coronary occlusion

¹Clinic of Surgery, National Heart and Lung Institute, Bethesda, Md. 20014.

The Annals of Thoracic Surgery

|July 1, 1975

Summary

Subendocardial ischemia, measured by S-T segment elevation, is maintained at higher blood pressures, unlike epicardial ischemia. Hemodynamic changes affect these two regions differently during coronary occlusion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neutrophil inhibition contributes to cardioprotection by postconditioning.

Acta anaesthesiologica Scandinavica·2011

Same author

Off pump coronary artery bypass surgery for significant left ventricular dysfunction: safety, feasibility, and trends in methodology over time--an early experience.

Heart (British Cardiac Society)·2005

Same author

Remote postconditioning. Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors.

Basic research in cardiology·2005

Same author

Off-pump coronary artery bypass grafting provides complete revascularization with reduced myocardial injury, transfusion requirements, and length of stay: a prospective randomized comparison of two hundred unselected patients undergoing off-pump versus conventional coronary artery bypass grafting.

The Journal of thoracic and cardiovascular surgery·2003

Same author

Brief pretreatment of radial artery conduits with phenoxybenzamine prevents vasoconstriction long term.

The Annals of thoracic surgery·2002

Same author

Predictors and outcomes associated with early extubation in older adults undergoing coronary artery bypass surgery.

American journal of critical care : an official publication, American Association of Critical-Care Nurses·2001

Area of Science:

Cardiology
Physiology

Background:

Subendocardial ischemia is a critical concern in cardiovascular disease.
Understanding regional differences in myocardial ischemia is vital for effective treatment.

Purpose of the Study:

To investigate the differential effects of hemodynamic changes on subendocardial versus epicardial ischemia during coronary occlusion.
To analyze S-T segment elevation as an indicator of myocardial ischemia in different cardiac regions.

Main Methods:

Utilized unipolar subendocardial electrodes in dogs to measure S-T segment elevations.
Induced coronary occlusion and manipulated heart rate, cardiac output, and blood pressure.
Quantitatively compared changes in subendocardial and epicardial S-T elevation.

Related Experiment Videos

Main Results:

Heart rate and cardiac output alterations produced similar S-T elevation changes in both regions.
Increased blood pressure (75 to 100 or 125 mm Hg) reduced epicardial S-T elevation more than subendocardial S-T elevation (p < 0.01).
Subendocardial ischemia persisted while epicardial ischemia decreased under elevated arterial pressures.

Conclusions:

Hemodynamic manipulations can lead to quantitatively distinct responses in subendocardial and epicardial S-T segment elevation.
Subendocardial ischemia is less responsive to increases in arterial pressure compared to epicardial ischemia.
These findings highlight regional differences in myocardial ischemia during coronary occlusion.