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Giant calcifying epithelioma

C T Sasaki1, A Yue, R Enriques

  • 1Department of Surgery, Yale University School of Medicine, New Haven, Conn 06510.

Archives of Otolaryngology (Chicago, Ill. : 1960)
|December 1, 1976
PubMed
Summary

Giant calcifying epithelioma, a large form of benign pilomatrixoma, can exhibit malignant behavior. Tumor size is crucial for prognosis, warranting caution against misdiagnosis from benign-appearing samples.

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Area of Science:

  • Dermatopathology
  • Surgical Oncology

Background:

  • Calcifying epithelioma of Malherbe (pilomatrixoma) is typically a small, benign skin tumor.
  • Histologically characterized by shadow cells, basophilic cells, foreign body cells, and calcifications.

Observation:

  • Recent surgical literature suggests enlarged pilomatrixomas can display aggressive behavior.
  • Tumor dimension is identified as a significant factor influencing prognosis.
  • A specific case demonstrated the malignant potential of giant calcifying epithelioma.

Findings:

  • Giant calcifying epithelioma, a distinct clinical entity, shares histologic similarities with benign pilomatrixoma.
  • This variant exhibits malignant potential, contrary to the traditional view of pilomatrixoma.
  • Mixed histologic features in this variant have not been previously emphasized.

Implications:

  • The term "giant calcifying epithelioma" is proposed for this malignant variant.
  • Clinicians must be vigilant and not rely solely on preoperative samples, which may appear benign.
  • Awareness of the malignant potential of large pilomatrixomas is critical for patient management.

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