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Related Experiment Videos

Intranuclear inclusions in Bence Jones lambda plasma cell myeloma

H J Cohen1, L G Lefer

  • 1Department of Medicine, Duke University Medical Center, VA Hospital, Durham, N.C. 27705.

Blood
|January 1, 1975
PubMed
Summary

Newly identified pale intranuclear inclusions were observed in bone marrow plasma cells of a patient with lambda light chain myeloma. These inclusions contained Bence Jones lambda protein, suggesting anomalous intranuclear protein synthesis.

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Area of Science:

  • Hematology
  • Oncology
  • Cell Biology

Background:

  • Plasma cell myeloma is a malignancy of plasma cells.
  • Bence Jones protein is an abnormal protein produced by malignant plasma cells, often found in urine.
  • The presence and characteristics of cellular inclusions can provide insights into disease mechanisms.

Observation:

  • A patient with plasma cell myeloma producing only Bence Jones lambda protein exhibited pale intranuclear inclusions in most bone marrow plasma cells.
  • These inclusions were previously undescribed in myeloma patients with this specific protein production profile.
  • The inclusions were characterized as non-electron dense, single-membrane bound structures without cytoplasmic components.

Findings:

  • Immunohistochemical analysis confirmed the presence of Bence Jones lambda protein within the intranuclear inclusions.

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  • No intracytoplasmic inclusions were observed, and the perinuclear cistern remained undilated.
  • The morphology and content suggest these inclusions represent intranuclear protein synthesis.

    • Implications:

    • These findings expand the understanding of protein synthesis anomalies in plasma cell myeloma.
    • The presence of intranuclear inclusions may serve as a potential diagnostic or prognostic marker.
    • Further research is warranted to elucidate the exact mechanism of anomalous protein release and its clinical significance.