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Limited effects of temafloxacin compared with ciprofloxacin on T-lymphocyte function
1Department of Medical Microbiology, Lund University, Malmö General Hospital, Sweden.
Abstract:
Temafloxacin increased interleukin-2 production and mRNA levels and enhanced thymidine incorporation in stimulated lymphocyte cultures. Gamma interferon mRNA levels were unaffected. Temafloxacin also stimulated interleukin-2 gene induction, as revealed in a chloramphenicol acetyltransferase reporter gene system. However, temafloxacin exerted significantly weaker effects in these respects than did ciprofloxacin.
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