Cocaethylene: a current understanding of the active metabolite of cocaine and ethanol

Cocaine and ethanol abuse remains a major problem in our society. The active metabolite of the co-ingestion of cocaine and ethanol, cocaethylene, has been reported recently. This active and potentially toxic metabolite has enormous implications for emergency physicians. This article is a brief review of the current understanding of cocaethylene and its role as a serious toxin in the practice of emergency medicine.