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Rheumatic manifestations of malignancy
1Medical Professorial Unit, St. Vincent's Hospital, Darlinghurst, NSW, Australia.
Current Opinion in Rheumatology
|January 1, 1994
Summary
Cancer therapies can cause rheumatic issues like inflammatory arthritis. This review highlights cancer associations with systemic sclerosis, Sjögren
Area of Science:
- Rheumatology
- Oncology
- Immunology
Background:
- Cancer therapies, including immunotherapies (Interleukin-2, interferon alfa, Calmette-Guérin bacillus), are associated with rheumatic conditions.
- Systemic sclerosis shows an increased incidence of cancers, particularly lung and breast cancer.
- Rheumatologic manifestations are linked to lymphoproliferative disorders and specific cancers.
Purpose of the Study:
- To review the rheumatic associations of cancer therapy.
- To explore the link between Sjögren's syndrome and lymphoproliferative disorders.
- To discuss paraneoplastic syndromes in various cancers.
Main Methods:
- Review of existing literature on cancer therapy and rheumatic diseases.
- Analysis of retrospective studies on cancer incidence in systemic sclerosis.
- Evaluation of studies on lymphoproliferative associations in Sjögren's syndrome.
Main Results:
- Immunotherapies can induce inflammatory arthritis; breast cancer therapy may lead to septic arthritis.
- Confirmed increased cancer incidence in systemic sclerosis, notably lung and breast cancers.
- B- and T-cell lymphomas present with rheumatologic symptoms like polyarthritis and sacroiliitis.
Conclusions:
- Understanding the rheumatic complications of cancer and its treatments is crucial.
- Further research is needed to elucidate the mechanisms behind these associations.
- Early recognition of rheumatic symptoms may aid in cancer diagnosis and management.