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Renal disease and rheumatic manifestations
1Professorial Department of Rheumatology, Royal North Shore Hospital, NSW, Sydney, Australia.
Current Opinion in Rheumatology
|January 1, 1994
Summary
Renal failure causes musculoskeletal issues in bone, joints, and soft tissues. Long-term dialysis patients may develop destructive cervical spondyloarthropathy due to beta 2-microglobulin amyloidosis.
Area of Science:
- Nephrology
- Rheumatology
- Orthopedics
Background:
- Renal failure significantly impacts musculoskeletal tissues, leading to conditions like avascular necrosis, osseous abnormalities, ligamentous laxity, destructive arthropathies, and soft-tissue calcifications.
- Therapeutic advancements such as dialysis and transplantation have introduced new musculoskeletal complications.
Purpose of the Study:
- To review the diverse musculoskeletal effects of renal failure.
- To highlight emerging disorders in patients undergoing renal replacement therapy.
- To focus on destructive cervical spondyloarthropathy in long-term hemodialysis patients.
Main Methods:
- Literature review of musculoskeletal manifestations in renal failure.
- Analysis of complications associated with dialysis and transplantation.
- Examination of the specific pathology of beta 2-microglobulin amyloidosis in the cervical spine.
Main Results:
- Musculoskeletal effects include bone, joint, and soft tissue abnormalities.
- Destructive cervical spondyloarthropathy is a prevalent and serious issue in long-term hemodialysis patients.
- Beta 2-microglobulin amyloidosis is implicated as a potential cause of this cervical pathology.
Conclusions:
- Renal failure presents a spectrum of musculoskeletal complications affecting various tissues.
- Long-term hemodialysis necessitates vigilance for specific conditions like destructive cervical spondyloarthropathy.
- Understanding the link between beta 2-microglobulin amyloidosis and cervical disease is crucial for patient management.