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Adaptation of signal transduction in brain
C Alling1, L Gustavsson, C Larsson
1Dept. of Psychiatry and Neurochemistry, Lund University, Sweden.
EXS
|January 1, 1994
Abstract:
Cell culture models were used to study the effects of long-term ethanol exposure on neuronal cells. Effects on phospholipase C and phospholipase D mediated signal transduction were investigated by assaying receptor-binding, G protein function, activities of lipases, formation of second messengers and c-fos mRNA. The signal transduction cascades displayed abnormal activities from 2 to 7 days of exposure which differed from the acute effects. Phosphatidylethanol formed by phospholipase D is an abnormal lipid that may harmfully affect nerve cell function.