Ultrafast computed tomography for the physiological evaluation of myocardial perfusion

Quantitation of myocardial blood flow has been sought by the clinician using a variety of imaging modalities and blood indicator dilution techniques. Ultrafast computed tomography has real potential for clinically useful estimations of regional myocardial blood flow. At the present time, there are limitations with this technique and early washout of indicator (iodine) appears to be the most likely explanation for the inaccuracies observed. Several methods have been tried to correct for early washout without success. Preliminary data based on a new algorithm look promising. Currently available techniques for detecting and quantifying myocardial ischemia have significant limitations. A noninvasive method able to determine wide ranges of flow with accuracy will be essential to understand the pathophysiology of ischemia and for directing better methods of managing ischemic heart disease.