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Intergenic DNA and the sequence requirements for replication initiation in eukaryotes
1Department of Genetics, University of Washington, Seattle 98195.
Current Opinion in Genetics & Development
|April 1, 1994
Abstract:
Replication in eukaryotes initiates at many origins per chromosome. The locations of most of these origins appear to be restricted to intergenic spacers. In this review, I propose that the sequence dependence of initiation seen in lower eukaryotes may be a by-product of the small size of intergenic sequences and may not reflect a general requirement of the mechanisms that control the initiation of replication.