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Cell surface receptor for ecotropic host-range mouse retroviruses: a cationic amino acid transporter
M P Kavanaugh1, H Wang, C A Boyd
1Department of Biochemistry, Oregon Health Sciences, University Portland.
Archives of Virology. Supplementum
|January 1, 1994
Abstract:
The cell surface receptor for ecotropic host-range murine leukemia viruses is a sodium-independent transporter for essential cationic acids. Our evidence strongly identifies this receptor as the transporter system y+, which was previously characterized by transport assays. Mutational analysis indicates that transporter activity is not necessary for viral reception. Infection of cells with ecotropic retroviruses causes only a partial down-modulation of receptor expression on cell surfaces.