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Rabbit as a model of urinary bladder function

R M Levin1, F C Monson, P A Longhurst

  • 1Division of Urology, University of Pennsylvania School of Medicine, Philadelphia.

Neurourology and Urodynamics
|January 1, 1994
PubMed
Summary
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This review explores the rabbit as a model for studying the complex neuromuscular process of micturition. Rabbits offer valuable insights into normal and pathological urinary tract functions.

Area of Science:

  • Urology
  • Neuroscience
  • Animal Models

Background:

  • Micturition is a complex neuromuscular process controlled by the central nervous system and spinal cord.
  • Autonomic innervation of the urinary bladder is the final pathway for micturition control.
  • Urinary bladder function, including contraction and efficient emptying, is crucial for normal micturition.

Purpose of the Study:

  • To review the utility of the rabbit as an animal model in urological research.
  • To describe how rabbits can be used to study normal and pathological functions of the lower urinary tract.
  • To provide a rational basis for employing rabbits in micturition research.

Main Methods:

  • Review of existing literature on rabbit models in urology.
  • Analysis of in vivo and in vitro studies involving the rabbit urinary system.

Related Experiment Videos

  • Examination of how experimental pathologies are studied in rabbit lower urinary tract models.

    • Main Results:

    • Rabbits have been widely used in developing various in vivo and in vitro models for urological research.
    • These models are instrumental in describing the effects of specific experimental pathologies on the lower urinary tract.
    • The rabbit serves as a suitable species for investigating both normal and pathological aspects of micturition.

    Conclusions:

    • The rabbit is a valuable animal model for urological research, particularly for studying micturition.
    • Its utility extends to understanding the autonomic control and functional dynamics of the urinary bladder.
    • Further research utilizing rabbit models can advance our knowledge of lower urinary tract disorders.