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Related Experiment Videos

Rat: overview and innervation

W D Steers1

  • 1Department of Urology, University of Virginia, Health Sciences Center, Charlottesville 22908.

Neurourology and Urodynamics
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Whole animal models, particularly rats, are crucial for understanding integrated urinary tract function. This review covers methods for studying lower urinary tract function and creating disease models in rodents.

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Area of Science:

  • Physiology
  • Pharmacology
  • Urology

Background:

  • Molecular and cellular methods are advancing, but whole animal models are essential for studying integrated physiological processes.
  • The rat is a cost-effective and adaptable animal model for investigating the urinary tract.
  • Rodent models exist for numerous lower urinary tract disorders, including diabetes, aging, and spinal cord injury.

Purpose of the Study:

  • To review methodologies for evaluating lower urinary tract function in animal models.
  • To examine techniques for creating pathological conditions affecting the urinary tract in rodents.
  • To highlight the importance of whole animal models in urological research.

Main Methods:

  • Review of existing literature on rodent models of urinary tract disorders.

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  • Analysis of techniques used to assess bladder and urethral function.
  • Examination of methods for inducing pathological changes in the rodent urinary tract.

    • Main Results:

    • The rat serves as a valuable model for studying integrated lower urinary tract physiology and pathophysiology.
    • Various methodologies exist to assess urodynamics and drug responses in rodent models.
    • Established protocols allow for the creation of relevant pathological conditions in rodents.

    Conclusions:

    • Whole animal models, especially rats, remain indispensable for understanding complex urinary tract functions.
    • The methodologies reviewed provide a foundation for future research in urological disease.
    • Rodent models are critical for preclinical evaluation of treatments for lower urinary tract disorders.