[Evaluation of 1993 FIVNAT]

FIVNAT registry collected information on 24,921 individual assisted reproductive technology (ART) cycles in 1993 and the present analysis concerns 17,102 cycles arrived on time to be incorporated, 95.5% being in vitro fertilization (IVF) cycles. The positive ponction rate for IVF (98.5%) and the transfer rate (80.1%) were not modified. The clinical pregnancy rates progressed to 20.4% per oocyte recovery cycle and to 25.5% per transfer, they were clearly increasing from 1992. The mean oocyte number (8.8 +/- 5.5) and the mean embryo number (4.02 +/- 3.81) were slightly increasing, but the mean number of transferred embryos was not modified (2.73 +/- 1.09). That confirms the transfer strategy of clinics. In 1993, the proportion of infertilities of tubal origin decreased (56.6% vs 58.9 in 1992), and those of male origin increased (37.5% vs 32.6% in 1992). The pregnancy rate increased for all the indications, especially for cycles realised with donor semen, except for the immunological one. Most of the stimulation regimen used the GnRH analogues protocols with a long blocking period (73.5%): they obtained the highest pregnancy rate per transferred embryo (24.6%). An increasing proportion of transfers involving 3 embryos was notified (39.1% vs 37.9% in 1992); the clinical pregnancy rates per transferred embryo were increasing since the last two years for transfers involving one to three embryos. The analysis of 11,405 clinical pregnancies resulting from recoveries realised between 1986 and 1992 showed a preterm birth rate of 9.3% for singleton, but a still high rate for twins and multiple pregnancies.(ABSTRACT TRUNCATED AT 250 WORDS)