Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human interleukin 4

J Banchereau1, F Brière, J P Galizzi

  • 1Schering-Plough, Laboratory for Immunological Research, Dardilly, France.

Journal of Lipid Mediators and Cell Signalling
|February 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficiency of the traditional practice of traps to stimulate black truffle production, and its ecological mechanisms.

Scientific reports·2022
Same author

Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

Redox biology·2017
Same author

Glycation stimulates cutaneous monocyte differentiation in reconstructed skin in vitro.

Mechanisms of ageing and development·2017
Same author

Resampling: An improvement of importance sampling in varying population size models.

Theoretical population biology·2016
Same author

How the truffle got its mate: insights from genetic structure in spontaneous and planted Mediterranean populations of Tuber melanosporum.

Molecular ecology·2016
Same author

In vitro Activation of B-CLL Cells.

Leukemia & lymphoma·2016
Same journal

Possible mechanisms for the differential effects of high linoleate safflower oil and high alpha-linolenate perilla oil diets on platelet-activating factor production by rat polymorphonuclear leukocytes.

Journal of lipid mediators and cell signalling·1998
Same journal

Characterization and representative structures of N-oligosaccharides bound to apolipoprotein H.

Journal of lipid mediators and cell signalling·1998
Same journal

Activation of PKC, superoxide anion production and LDL lipid peroxidation are not dependent on phosphoinositide-specific phospholipase C activity in U937 cells.

Journal of lipid mediators and cell signalling·1998
Same journal

Mechanism of arachidonic acid-induced Ca2+ mobilization in liver nuclei.

Journal of lipid mediators and cell signalling·1998
Same journal

The acute increases in vasomotor tone and blood pressure induced by carotid artery occlusion are modulated by platelet-activating factor (PAF) independently of nitric oxide release.

Journal of lipid mediators and cell signalling·1998
Same journal

Erythropoietin stimulates nuclear localization of diacylglycerol and protein kinase C beta II in B6SUt.EP cells.

Journal of lipid mediators and cell signalling·1998
See all related articles

Human Interleukin-4 (IL-4) is a cytokine secreted by T cells that influences immune responses and cell differentiation. It plays a key role in IgE production and may have anti-tumoral and anti-inflammatory applications.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Human Interleukin-4 (IL-4) is a pleiotropic cytokine secreted by activated T cells.
  • IL-4 affects various immune cells, including T and B lymphocytes, monocytes, and endothelial cells.
  • Its functions are context-dependent, influenced by other cytokines like IL-2 and interferon-gamma.

Purpose of the Study:

  • To describe the characteristics and functions of human IL-4.
  • To elucidate the role of IL-4 in immunoglobulin E (IgE) production.
  • To identify the high-affinity receptor for IL-4.

Main Methods:

  • Review of in vitro and in vivo experimental data from mouse and human studies.
  • Analysis of cytokine interactions, specifically IL-4 with IL-2 and interferon-gamma.

Related Experiment Videos

  • Characterization of the IL-4 receptor.

    • Main Results:

    • IL-4 is crucial for inducing IgE production, an effect counteracted by interferons.
    • Human IL-4 binds to a high-affinity receptor, a glycoprotein of the hematopoietin receptor superfamily.
    • IL-4 exhibits pleiotropic effects on diverse cell types and at various differentiation stages.

    Conclusions:

    • Human IL-4 is a key regulator of IgE production and immune cell function.
    • The IL-4 receptor is a member of the hematopoietin receptor superfamily.
    • IL-4 demonstrates potential as an anti-tumoral and anti-inflammatory therapeutic agent.