[In vitro drug sensitivity testing and chemotherapy of lung cancer]

100 lung cancer operated fresh specimens were collected for in vitro drug sensitivity testing, most of them were NSCLC. Those drugs were MMC(M), ADM(A), PDD(P) and VCR(O). 42% of them were sensitive to 2-4 drugs, but 39% were not sensitive to any of the 4 drugs, the sensitive rate of ADM was higher, 41%, MMC, VCR, and PDD were 37% and 32% respectively, but with no statistical meaning. There were 9 sensitive chemotherapy combination, MAPO combination was the highest, 73.8% of the specimens was sensitive to ADM and PDD, 73.8% of the combination included MMC. The in vitro sensitive drugs and sensitive rate were corresponded to the response rate on NSCLC clinically. As above-mentioned, it convinces us that in vitro drugs sensitivity may be meaningful for the design of combination chemotherapy regimen and developing new drugs for lung cancer.