Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phialophora mutabilis endocarditis

M Slifkin, H M Bowers

    American Journal of Clinical Pathology
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    This study reports the first case of fungal endocarditis caused by Phialophora mutabilis on a prosthetic mitral valve. The infection led to valve obstruction and patient death, highlighting a rare but serious complication of prosthetic heart valves.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Changing Beliefs About Emotions in IBS: A Single Case Design.

    Behavioural and cognitive psychotherapy·2018
    Same author

    Late and atypical cytomegalovirus disease in solid-organ transplant recipients.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2001
    Same author

    Tween 80 opacity test responses of various Candida species.

    Journal of clinical microbiology·2000
    Same author

    Evaluation of a water-extracted pharmamedia agar medium for the culture of fungi.

    Diagnostic microbiology and infectious disease·2000
    Same author

    U.S. case report of cerebral phaeohyphomycosis caused by Ramichloridium obovoideum (R. mackenziei): criteria for identification, therapy, and review of other known dematiaceous neurotropic taxa.

    Journal of clinical microbiology·1998
    Same author

    Comparison of the Histopaque-1119 method with the Plasmagel method for separation of blood leukocytes for cytomegalovirus isolation.

    Journal of clinical microbiology·1992
    Same journal

    Invasive urothelial carcinoma in association with surface low-grade papillary urothelial carcinoma: clinical and pathologic insights from a rare entity.

    American journal of clinical pathology·2026
    Same journal

    CEACAM1 expression by immunohistochemistry in B-cell lymphomas and plasma cell myeloma.

    American journal of clinical pathology·2026
    Same journal

    Comprehensive multicriteria life cycle assessment of biopsy processing in a surgical pathology department.

    American journal of clinical pathology·2026
    Same journal

    Prognostic significance of Myb protein and its downstream target genes in lacrimal gland adenoid cystic carcinoma.

    American journal of clinical pathology·2026
    Same journal

    Mismatch repair protein "nonclassic expression loss" pattern in colorectal cancer: an important staining pattern that is not well understood.

    American journal of clinical pathology·2026
    Same journal

    Musculoskeletal pain in medical laboratory personnel: a cross-sectional study.

    American journal of clinical pathology·2026
    See all related articles

    Area of Science:

    • Mycology
    • Cardiology
    • Infectious Diseases

    Background:

    • Fungal endocarditis is a rare but serious infection of heart valves.
    • Prosthetic heart valves are susceptible to fungal colonization.
    • Phialophora mutabilis is a dematiaceous fungus not previously implicated in endocarditis.

    Purpose of the Study:

    • To report the first case of fungal endocarditis caused by Phialophora mutabilis on a prosthetic mitral valve.
    • To describe the clinical presentation, diagnosis, and outcome of this rare infection.
    • To characterize the morphology and pathogenicity of the isolated Phialophora mutabilis strain.

    Main Methods:

    • Case report of a patient with rheumatic heart disease and prosthetic valves.
    • Surgical explantation of the prosthetic mitral valve with vegetation analysis.

    Related Experiment Videos

  • Microscopic and cultural identification of the causative fungus.
  • Inoculation of Phialophora mutabilis into cortisone-treated and untreated mice.

    • Main Results:

    • A large, obstructive fungal vegetation of Phialophora mutabilis was found on the prosthetic mitral valve.
    • The patient developed congestive heart failure and died postoperatively.
    • Phialophora mutabilis exhibited variations in morphology and pigmentation.
    • Cortisone-treated mice showed higher mortality rates after inoculation compared to untreated mice.

    Conclusions:

    • Phialophora mutabilis can cause severe fungal endocarditis on prosthetic heart valves.
    • Early diagnosis and aggressive management are crucial for improving outcomes.
    • Further research is needed to understand the pathogenicity and treatment of Phialophora mutabilis infections.