Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A model for pterygium formation

L S Kwok1, M T Coroneo

  • 1Corneal Physiology and Biophysics Laboratory, College of Optometry, University of Houston, TX 77204-6052.

Cornea
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consecutive dosing of UVB irradiation induces loss of ABCB5 expression and activation of EMT and fibrosis proteins in limbal epithelial cells similar to pterygium epithelium.

Stem cell research·2022
Same author

Distribution of conjunctival ultraviolet autofluorescence in a population-based study: the Norfolk Island Eye Study.

Eye (London, England)·2011
Same author

Miyake-Apple study of the rotational stability of the Acrysof Toric intraocular lens after experimental eye trauma.

Eye (London, England)·2009
Same author

Multichannel surface recordings on the visual cortex: implications for a neuroprosthesis.

Journal of neural engineering·2008
Same author

Preventing conjunctival autograft inversion in pterygium surgery.

The British journal of ophthalmology·2006
Same author

Mechanosensitivity and the eye: cells coping with the pressure.

The British journal of ophthalmology·2006
Same journal

Corneal Tissue Addition Keratoplasty.

Cornea·2026
Same journal

Corneal Tissue Addition Keratoplasty for Keratoconus: Point-Counterpoint.

Cornea·2026
Same journal

Posterior Segment Pressurization With Intravitreal Balanced Salt Solution to Stabilize Anterior Chamber Gas During Endothelial Keratoplasty.

Cornea·2026
Same journal

Central Corneal Thickness Six Postoperative Months After DMEK or Triple-DMEK.

Cornea·2026
Same journal

Rebubbling and Graft Detachment in Pre-Descemet Endothelial Keratoplasty: A Prospective Study.

Cornea·2026
Same journal

Letter Regarding: ESCALÓN: A Prospective Randomized Trial of Corneal Endothelial Cell Therapy in Subjects With Corneal Edema.

Cornea·2026
See all related articles

This study models pterygium formation, proposing chronic UV light alters limbal stem cells. This leads to conjunctivalization of the cornea, explaining the wing-shaped growth observed in pterygium.

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Cell Biology

Background:

  • Pterygium is a wing-shaped fibrovascular growth on the cornea.
  • Its pathogenesis is linked to environmental factors, particularly UV radiation.
  • The role of limbal stem cells in pterygium formation requires further elucidation.

Purpose of the Study:

  • To model the formation of a pterygium using a population balance model.
  • To investigate the hypothesis that focused light alters corneal epithelial stem cells.
  • To simulate light-induced conjunctival epithelial proliferation and its effect on corneal surface.

Main Methods:

  • A population balance model was developed for corneal and limbal epithelial production.
  • Rabbit corneal data were used to implement light-induced conjunctival epithelial proliferation.

Related Experiment Videos

  • A computational algorithm normalized attrition rates and simulated cell migration and mass formation.

    • Main Results:

    • The model successfully simulated a wing-shaped mass with a curved leading edge.
    • Simulated epithelial cell production showed a ten-fold peak stimulation at the nasal limbus.
    • The model predicted cell migration and accumulation consistent with pterygium growth.

    Conclusions:

    • Chronic ultraviolet light exposure may alter limbal stem cells, initiating pterygium pathogenesis.
    • Breakdown of the limbal barrier and conjunctivalization of the cornea explain pterygium formation.
    • The study provides a computational model for understanding pterygium development.