[The protective effects of two hydration protocols against cisplatin nephrotoxicity]

A comparative study was performed in 37 patients with breast cancer who received high doses of cisplatin (100 mg/m2, I.V. drip) accompanied by two different hydration protocols. The new hydration protocol is based on the study of relationship between the pharmacokinetic parameters of plasma and urinary platinum concentration and the cisplatin-induced nephrotoxicity. In the new hydration protocol the diuretic drugs were given twice- amid and twelve hours after the cisplatin infusion instead of giving once--immediately after the cisplatin infusion, and 1,000ml drinking water was given by p.o. before taking cisplatin. Because of the increase in urinary volume the peak levels of urinary platinum were decreased from 47.34 micrograms/ml to 13.49 micrograms/ml, so that the rate of the nephrotoxicity was reduced from 36.8% (7/19) to 5.6% (1/18). The results suggest that the new hydration protocol is more effective than that previously used to protect against cisplatin nephrotoxicity.