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The radiation dosimetry and normal value study of 99mTc-HMPAO-labeled leukocytes
M L Brown1, J C Hung, R J Vetter
1Department of Diagnostic Radiology, Mayo Clinic and Foundation, Rochester, Minnesota.
Rationale And Objectives:
Indium-111 (111In)-labeled leukocyte scanning has been used frequently in patients suspected of having infections. Recently, technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) has been used to label leukocytes. This study was undertaken to determine the distribution and dosimetry of 99mTc-HMPAO leukocytes in healthy subjects.
Methods:
Five healthy volunteers had leukocytes labeled with 99mTc-HMPAO. After injection of the labeled leukocytes, whole body images and blood and urine samples were obtained at multiple time points.
Results:
Visual interpretation of the images demonstrated significant bowel activity as early as 2 hours and increasing with time such that one the 8- and 24-hour images, the amount of bowel activity would preclude using 99mTc-HMPAO leukocyte scanning for abdominal processes. The dosimetry for this study is similar to that of other studies and is in an acceptable diagnostic range.
Conclusions:
99mTc-HMPAO leukocyte studies are an acceptable alternative to 111In-labeled leukocyte studies in terms of dosimetry. Use of such studies in the abdomen should be limited to early images, usually before 2 hours, to avoid confusion with the normal route of excretion in the bowel.