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Cytomegalovirus gastritis associated with pseudolymphoma
G M Zucker1, C Otis, K Korowski
1Department of Medicine, Baystate Medical Center, Springfield, MA 01199.
Journal of Clinical Gastroenterology
|April 1, 1994
Summary
Recurrent upper gastrointestinal bleeding was linked to cytomegalovirus (CMV) infection and pseudolymphoma in a patient. Ganciclovir treatment resolved the hemorrhage, highlighting the importance of diagnosing these conditions.
Area of Science:
- Gastroenterology
- Virology
- Pathology
Background:
- Recurrent upper gastrointestinal hemorrhage can stem from various causes, including infections and inflammatory conditions.
- Erosive gastritis is a known cause of gastrointestinal bleeding.
Observation:
- A patient presented with recurrent upper gastrointestinal hemorrhage despite standard treatments.
- Endoscopy revealed punctate hemorrhages and thickened gastric folds.
- Biopsies identified cytomegaloviral inclusions and later, lymphoid germinal formations consistent with pseudolymphoma.
Findings:
- The patient's bleeding was attributed to a combination of cytomegalovirus (CMV) infection and pseudolymphoma of the stomach.
- Standard treatments for hemorrhage were initially ineffective.
Implications:
- Prompt diagnosis and targeted antiviral therapy, such as ganciclovir, are crucial for managing CMV-related gastrointestinal bleeding.
- Pseudolymphoma should be considered in the differential diagnosis of thickened gastric folds, especially in the context of chronic inflammation or infection.
- Successful treatment with ganciclovir suggests its efficacy in resolving CMV-induced gastric pathology and associated bleeding.