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Fusobacterial infections in children
1Department of Pediatrics, Georgetown University School of Medicine, Washington, DC.
The Journal of Infection
|March 1, 1994
Summary
Fusobacteria species, particularly Fusobacterium nucleatum, are prevalent in pediatric infections, often occurring in mixed infections. These bacteria are frequently found in abscesses and aspiration pneumonia, with most children recovering after treatment.
Area of Science:
- Microbiology
- Pediatric Infectious Diseases
Background:
- Fusobacteria are anaerobic bacteria that can cause various human infections.
- Understanding the prevalence and types of Fusobacteria in pediatric infections is crucial for effective treatment.
Purpose of the Study:
- To investigate the prevalence and characteristics of Fusobacteria species isolated from pediatric infections.
- To identify common infection sites and co-infecting organisms associated with Fusobacteria.
Main Methods:
- Retrospective analysis of 243 Fusobacteria strains from 226 pediatric specimens.
- Identification of Fusobacteria species and co-isolates.
- Correlation of bacterial findings with clinical data, infection sites, and predisposing conditions.
Main Results:
- Fusobacteria were recovered from 16% of pediatric specimens, with Fusobacterium nucleatum being the most common (59%).
- Common infection sites included abscesses, aspiration pneumonia, and skin/soft tissue infections.
- Mixed infections were common (92%), frequently involving anaerobic cocci, Prevotella/Porphyromonas species, and Bacteroides fragilis group.
Conclusions:
- Fusobacteria species are significant pathogens in pediatric infections, with Fusobacterium nucleatum being predominant.
- The study highlights the polymicrobial nature of these infections and common associated conditions.
- Prompt antimicrobial therapy and surgical intervention led to favorable outcomes in most cases.