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Albendazole in single CT ring lesions in epilepsy
M V Padma1, M Behari, N K Misra
1Department of Neurology, All India Institute of Medical Sciences, New Delhi.
Neurology
|July 1, 1994
Summary
Albendazole treatment did not benefit Indian patients with seizures and CT lesions likely due to cysticercosis. Most lesions resolved spontaneously regardless of treatment, indicating no added value from albendazole therapy.
Area of Science:
- Neurology
- Infectious Diseases
- Radiology
Background:
- Single, small, enhancing lesions on CT scans are common in Indian patients with seizures.
- These lesions are often spontaneous and likely represent cysticercosis based on ELISA and biopsy data.
Purpose of the Study:
- To evaluate the efficacy of albendazole in treating patients with seizures and CT lesions suggestive of cysticercosis.
Main Methods:
- A double-blind, randomized, placebo-controlled study was conducted with 75 patients.
- Patients received either albendazole (15 mg/kg/d) or placebo for 1 week, with serial CT scans at 1 week, 1 month, and 3 months.
Main Results:
- Forty patients received albendazole, and 35 received placebo; all completed 3-month follow-up.
- At 3 months, 68 patients showed lesion resolution: 35/40 on albendazole and 33/35 on placebo.
- Serum and CSF ELISA for cysticercosis were positive in a significant proportion of patients.
Conclusions:
- Albendazole therapy demonstrated no significant benefit in resolving CT lesions in patients with seizures.
- Spontaneous resolution of these lesions is common, suggesting albendazole is not necessary for this condition.