[Unusual defective antibody reaction after polio vaccination (author's transl)]

Over several years we have determined the titers of the neutralizing antibodies against the three types of polio virus in 147 adult females working in hospitals or laboratories. Through administration of a trivalent oral vaccine we attempted to boost the vaccination and supplement the missing antibodies. A strong antibody reaction against all three types of polio virus could only be obtained usually after an additional parenteral injection of inactivated serum. Four cases are described in detail as rare occurrences (2.7 percent of those investigated). For some unknown reason, the desired antibody formation could not be obtained in these subjects in spite of repeated administration of both types of vaccine.