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Treatment of ABO hemolytic disease with synthetic blood group trisaccharides
E L Romano1, A Soyano, R F Montaño
1Laboratory of Pathophysiology, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Venezuela.
Vox Sanguinis
|January 1, 1994
Abstract:
Thirteen infants, 10 with A-O and 3 with B-O hemolytic disease of the newborn (ABO-HDN), were treated with synthetic A or B blood group trisaccharides (ATS, BTS) which cause dissociation of maternal antibody bound to infant red cells. The clinical outcome was compared with that of a control group of 21 infants treated with phototherapy during the preceding year. Exchange transfusion was required in 2 out of 13 infants in the experimental group and in 7 in the control group. A randomized prospective controlled study is necessary to confirm these results.