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Related Experiment Videos

Antireflux operations in patients with scleroderma

N C Poirier1, R Taillefer, P Topart

  • 1Department of Surgery, Université de Montréal, Hôtel-Dieu de Montréal, Québec, Canada.

The Annals of Thoracic Surgery
|July 1, 1994
PubMed
Summary

Antireflux operations effectively relieved reflux symptoms and reduced acid exposure in scleroderma patients. These procedures improved esophagitis and stenosis without negatively impacting esophageal function.

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Area of Science:

  • Gastroenterology
  • Surgical Gastroenterology
  • Esophageal Surgery

Background:

  • Scleroderma often leads to gastroesophageal reflux disease (GERD) and associated complications.
  • Scleroderma patients present unique challenges for antireflux surgery due to underlying motility disorders.

Purpose of the Study:

  • To evaluate the efficacy and safety of antireflux operations in patients with scleroderma.
  • To assess the impact of these operations on esophageal function and reflux symptoms.

Main Methods:

  • Fourteen scleroderma patients underwent various antireflux procedures.
  • Preoperative and postoperative assessments included symptom evaluation, 24-hour esophageal acid exposure, manometry, radiology, endoscopy, and radionuclide transit studies.

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Main Results:

  • Reflux symptoms were relieved in 10 of 14 patients, with a significant decrease in 24-hour esophageal acid exposure.
  • Radiologic signs of stenosis regressed in 6 of 7 patients, and endoscopic healing of erosions and ulcers was observed.
  • While distal esophageal resting pressure increased, suggesting stasis, radionuclide transit studies showed no significant decrease in esophageal emptying capacity.

Conclusions:

  • Conventional antireflux operations can successfully palliate reflux damage in scleroderma patients.
  • These surgical interventions appear safe for esophageal function in this patient population.
  • Antireflux surgery offers a viable option for managing GERD complications in scleroderma.