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Presence of dityrosine bridges in thyroglobulin and their relationship with iodination
A Leonardi1, R Acquaviva, M Marinaccio
1Dipartimento di Biologia e Patologia Cellulare e Molecolare L. Califano, C.N.R. II Facoltà di Medicina e Chirurgia, Napoli, Italy.
Biochemical and Biophysical Research Communications
|July 15, 1994
Abstract:
The presence of dimeric thyroglobulin (19S), after reduction and alkylation, suggests that within thyroglobulin there may be intermolecular cross-links, other than disulphide bridges. However, the nature of these intermolecular cross-links is still unknown. In this study, we show the presence of 3-3' dityrosine bridges in the molecule of bovine thyroglobulin by NMR and fluorescence studies. Also, we evaluated the role of iodination in dityrosine formation in vivo and in vitro.