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[Carcinosarcoma arising in eccrine spiradenoma. A morphologic and immunohistochemical study]
M Huerre1, D Bonnet, S W Mc Carthy
1Laboratoire d'Anatomie Pathologique, Institut Pasteur de Nouméa.
Annales De Pathologie
|January 1, 1994
Summary
Malignant transformation of benign eccrine spiradenoma is rare, with 23 cases reported. Recent changes in these cutaneous nodules can indicate underlying carcinoma, sometimes leading to fatal outcomes.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Eccrine spiradenoma is a benign adnexal tumor.
- Malignant transformation into carcinoma is a documented, albeit rare, event.
Observation:
- This study reports a case of carcinosarcoma arising in a benign eccrine spiradenoma.
- The patient presented with recent changes in a long-standing cutaneous nodule.
Findings:
- Histologic examination revealed squamous cell carcinoma associated with osteosarcoma in the recurrence.
- Malignant eccrine spiradenoma can present with aggressive features, including carcinosarcoma.
Implications:
- Early recognition of changes in benign eccrine spiradenoma is crucial for timely diagnosis and management.
- Understanding the diverse histologic presentations of malignant eccrine spiradenoma is important for prognosis.