Involvement of nitric oxide-formation in the action of losartan (DuP 753): effects in an inhibitory avoidance model

The potent and selective orally active ANG II receptor antagonist losartan (DuP 753) enhanced the retentions in an inhibitory (passive) avoidance test after scopolamine amnesia. In addition, the influence of the specific NO-synthase inhibitor NG-nitro-L-arginine (L-NNA) in combination with losartan was tested. L-NNA itself shows no effect. The combination of losartan with L-NNA did not produce any prolongation of step-through latencies.